RIGHT-CLICK on the MY COMPUTER icon and click on PROPERTIES.  
Select the HARDWARE tab, then the DEVICE MANAGER button.  
Remove the Epson Scanner from under IMAGING DEVICE and/or UNKNOWN and/or OTHER DEVICES by RIGHT-CLICKING on it and clicking UNINSTALL.  
Disconnect the USB cable and close all open windows.  
Click on START, and CONTROL PANELS.  
Double-click on ADD/REMOVE PROGRAMS. Highlight EPSON SCAN and click on CHANGE/REMOVE.  
Go to START, SEARCH, and ALL FILES AND FOLDERS. Select Advanced option and ensure there is a checkmark next toSEARCH HIDDEN FILES and FOLDERS.  
Search for files where all or part of the file named is OEM*.* and a word or phrase in the file contains EPSON. Search location should be set to C :\WINDOWS\INF or C :\WINNT\INF.  
Delete all files that are found if this is your only Epson product. If you have another Epson product, you will want to open each individual file and determine which files pertain to your scanner, and then delete only those.  
Go to START, SEARCH, and ALL FILES AND FOLDERS. Search for files where all or part of the file named twain.log . Search location should be set to C :\. Please delete the twain.log file and repeat the process for twain001.mtx, twunk001.mtx and twunk002.mtx. and epfb5 and escndv  
 
Now we need to remove specific references to the product in the registry :  
 
Click on START and then RUN.  
In the Run window type in REGEDIT.  
In the upper menu bar click on FILE, then EXPORT.  
In the window that comes up, SAVE IN should be set to DESKTOP.  
In the FILE NAME section at the bottom of the window type in REGBACKUP.  
EXPORT RANGE should have a dot next to ALL.  
Click on SAVE.  
Look in the column on the left and Click on the "+" sign next to HKEY_CURRENT_USER  
Click on the "+" sign next to SOFTWARE  
Click on the "+" sign next to Epson  
Look for a folder name EPSON SCAN or epson twain . Right click on it and Delete it (if you don’t see it, then don’t worry about it).  
If you see a reference to your Epson product model, right click and delete it.  
Click on the "-" signs next to EPSON, SOFTWARE, HKEY_CURRENT_USER to close up this branch.  
Click on the "+" sign next to HKEY_LOCAL_MACHINE  
Click on the "+" sign next to SOFTWARE  
Click on the "+" sign next to Epson  
Look for a folder name EPSON SCAN or epson twain , Right click on it and Delete it (if you don’t see it, then don’t worry about it).  
If you see a reference to your Epson product model, right click and delete it.  
Click on the "-" signs next to EPSON, SOFTWARE, HKEY_LOCAL_MACHINE to close up this branch